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Cleanroom Air Filtration Systems | YONGFAN
Controlled Environments · Staged Filtration · Passive Terminals & FFUs · ISO 14644 Preparation

Cleanroom Air Filtration Systems: Staged Contamination & Airflow Control

A cleanroom does not achieve its required particle condition because one HEPA filter has a high efficiency rating. The entire air path must control contamination, pressure, airflow distribution and filter integrity from the AHU to the room.

Coordinate primary pre-filters (CG, CCB, CY, CNL, CJS), medium-efficiency filters (ZF bag 600mm, ZZH V-bank 295mm, ZDZ mini-pleat), scan-tested HEPA/ULPA filters, GFK passive supply diffusers (500–3,000 m³/h), GCFK ultra-thin 150mm terminals, distributed FFU fan filter units (900 m³/h, ≤54 dB(A)), and pressure relief dampers.

Staged Stages G4 Pre + F8 Medium + HEPA
GFK Terminals 500–3,000 m³/h · Multi-Depth
GCFK Ultra-Thin 150 mm Depth · ≥99.99% MPPS
FFU Fan Filter 900 m³/h · ≤54 dB(A) · 220V
Cleanroom ceiling grid with HEPA diffusers and laminar flow filtration units in pharmaceutical facility
Cleanroom Air Systems Pre-Filters · Medium Bag/V-Banks · Terminal HEPA · GFK / GCFK Diffusers · FFUs
01 / Contamination Path Analysis

Cleanroom Failures Usually Occur Between the Filter Stages

A final HEPA filter passes factory scans, yet the room fails particle count if upstream stages overload, casing seals bypass, or room pressurization collapses.
Cleanroom HVAC air handling unit with multi-stage filter frames and differential pressure gauges
Five Cleanroom System Variables

Particle Sequence · Total Resistance · Terminal Architecture · Room Pressure · Air Distribution

Staging coarse pre-filtration, medium bag/V-bank filtration, and terminal HEPA/FFUs protects final filters and stabilizes room pressurization.

Stage Dust Overload

Omitting medium-efficiency filtration dumps coarse dust directly onto expensive terminal HEPA filters, rapidly consuming pressure budget.

Impact: Premature HEPA clogging, high replacement costs & airflow drop

Clean vs Dirty Sizing Collapse

Selecting the central fan based only on clean-filter resistance results in starved room airflow as dust loads the filter bank.

Impact: Loss of required cleanroom air changes per hour (ACH) over time

Passive vs FFU Architectural Mismatch

Installing passive HEPA boxes without sufficient AHU static pressure, or installing FFUs where central ducted pressure was already available.

Impact: Inadequate terminal face velocity or redundant electrical loads

Gasket & Frame Bypass Infiltration

Unsealed terminal housing joints, damaged gel seals, or negative room pressure pulling untreated air through wall/ceiling penetrations.

Impact: Failed ISO 14644 cleanroom particle count qualification

Five Control Variables in Cleanroom Design

Staged particle removal, total resistance budget, terminal selection, pressure control, and distribution.

01 / Staged Removal Coarse pre-filter (G4) -> Medium filter (F7/F8) -> Terminal HEPA/ULPA (H14/U15)
02 / Terminal Architecture Passive GFK/GCFK (central AHU pressure) vs Distributed FFU (local fan power)
03 / Room Pressurization Supply/exhaust balance with counterweighted residual-pressure relief dampers
04 / Molecular Control Upstream chemical gas-phase filtration where Airborne Molecular Contamination (AMC) is present
02 / Portfolio Showcase

Cleanroom Air Filtration Product Families

Detailed engineering review of YONGFAN’s pre-filters, medium filters, HEPA terminals, and FFUs.
01 · Pre-Filters Coarse Particulate Removal · G3/G4

Primary / Pre-Filters (CG, CCB, CY, CNL, CJS)

Stops coarse dust, lint, and large particles at the AHU fresh-air intake. Available in washable synthetic media, metal mesh, disposable pleated panels, and compact cartridge formats. Protects downstream medium and HEPA stages from rapid loading.

Filter Classes
ISO Coarse / G3 to G4
Media Types
Washable Synthetic, Metal Mesh, Pleated Fibers
Frame Construction
Galvanized Steel, Aluminum Alloy, Cardboard
Initial Resistance
Low Initial Pressure Drop (30–60 Pa)
Primary Applications

AHU fresh-air intakes, recirculating air returns, and pre-filtration for cleanroom air handlers.

02 · Medium Filters Sub-Micron Protection · F5–F9 / ePM1

Medium-Efficiency Filters (ZF, ZZH, ZDZ, ZYG)

The critical intermediate filtration stage. Includes ZF5–ZF9 synthetic bag filters (600 mm depth), ZZH compact V-bank filters (295 mm depth for tight AHUs), ZDZ mini-pleat panels, and ZYG separator box filters, capturing 1–10 µm dust before it reaches terminal HEPA stages.

Efficiency Range
F5 to F9 / ISO ePM2.5 & ePM1
ZF Bag Depth
600 mm Extended Pocket Media
ZZH V-Bank Depth
295 mm Compact High-Flow Configuration
Dust Holding
High Synthetic & Glass Fiber Capacity
Primary Applications

Cleanroom makeup AHUs, hospital supply air handlers, and commercial precision air systems.

03 · HEPA & ULPA Final Barrier · H13 to U16 · 100% Scan Tested

HEPA & ULPA High-Efficiency Filters

Final high-efficiency particle barrier. Scan-tested individually for pinhole leaks and frame-seal integrity per EN 1822 / ISO 29463. Available with polyurethane seamless endless gaskets, liquid gel seals for knife-edge grids, and mini-pleat fiberglass media.

Efficiency Classes
H13, H14, U15, U16 (≥99.99% @ MPPS)
Testing Protocol
100% Individual Pinhole Scan Tested
Sealing Systems
PU Seamless Gasket / Knife-Edge Gel Seal
Separator Types
Hot-Melt Mini-Pleat / Aluminum Separator
Primary Applications

Terminal ceiling diffusers, cleanroom FFU modules, laminar flow benches, and biosafety cabinets.

04 · GFK Diffusers Passive Terminal Box · 500–3,000 m³/h

GFK HEPA Supply-Air Diffuser Boxes

Passive ceiling-mounted HEPA terminal housing (500–3,000 m³/h). Relies on central AHU fan pressure. Available in casing depths of 69, 80, 150, and 220 mm; fabricated from cold-rolled steel (powder coated), galvanized, stainless steel (-S), or aluzinc (-AZ) with top or side inlet connections.

Airflow Range
500 to 3,000 m³/h Passive Supply
Casing Depths
69 mm, 80 mm, 150 mm, 220 mm Depths
Inlet Options
Top Inlet / Side Inlet with Round Spigot
Material Builds
Cold-Rolled Steel, Galvanized, SS (-S), Aluzinc (-AZ)
Primary Applications

Ducted cleanrooms where central AHUs provide required terminal static pressure, hospital operating rooms, and pharma suites.

05 · GCFK Ultra-Thin Shallow Ceiling Terminal · 150 mm Depth

GCFK Ultra-Thin HEPA Diffusers

Low-profile HEPA diffuser engineered for shallow ceiling voids (150 mm overall depth). GCFK-6 (610×610 mm, 600 m³/h), GCFK-9 (915×610 mm, 900 m³/h), and GCFK-12 (1220×610 mm, 1,200 m³/h) with ≤120 Pa initial DP and ≥99.99% MPPS efficiency (max 80 °C / 80% RH).

Shallow Profile
150 mm Overall Unit Depth
Standard Models
GCFK-6 (600 m³/h), GCFK-9 (900), GCFK-12 (1,200)
Initial Resistance
≤120 Pa Low Resistance
Efficiency Basis
≥99.99% MPPS High Efficiency
Primary Applications

Renovation projects, low-clearance ceiling plenums, and modular cleanroom ceiling grids.

06 · FFU Fan Filter Distributed Fan-Powered · 900 m³/h · ≤54 dB(A)

FFU Fan Filter Units

Integrates an internal backward-curved fan and H14 HEPA filter into one modular ceiling unit. Delivers 900 m³/h airflow, ≤54 dB(A) sound level, ≥99.99% @ 0.3 µm efficiency, ~180 VA power consumption on single-phase AC 220 V 50 Hz. Enables distributed fan power without high-pressure central ductwork.

Rated Airflow
900 m³/h per Standard Module
Acoustic Rating
≤54 dB(A) Quiet Operation
HEPA Rating
≥99.99% at 0.3 µm Particle Size
Electrical Load
~180 VA · AC 220 V ±10%, 50 Hz
Primary Applications

Large semiconductor cleanrooms, modular clean booths, laminar flow canopies, and distributed ceiling grids.

07 · Pressure & VAV Airflow & Pressure Balance · JG/T & VAV

Cleanroom Pressure & Airflow Controls

Counterweighted residual-pressure relief valves maintain positive room pressure by relieving excess air at set ΔP. YFVAV-S-T100 pressure-independent terminals (Ø125–Ø400, 122–6,232 m³/h) and YF-MOA plenums provide variable airflow control where cleanroom designs require dynamic zoning.

Pressure Relief
Counterweighted Residual-Pressure Valves
VAV Terminal
YFVAV-S-T100 (9 Sizes Ø125–Ø400)
Distribution
YF-MOA Multi-Outlet Plenums
AMC Treatment
Optional Upstream Chemical Filtration
Primary Applications

Airlock pressurization, cleanroom suite pressure cascading, and variable-airflow clean zones.

03 / Selection Routing

Cleanroom Terminal Selection Architecture Comparison

Compare passive HEPA supply boxes against distributed fan-powered FFU ceiling modules.
Selection QuestionGFK / GCFK Passive TerminalFFU Fan Filter Unit
Fan locationCentral AHU / upstream plant roomIntegrated local fan at ceiling module
Main pressure sourceCentral AHU fan carries terminal resistanceLocal FFU fan plus room return air path
Ceiling electrical loadPrimarily controls / BMS sensors onlyIndividual fan power required at every module
Central duct pressureMust carry full terminal HEPA resistance (~250–500 Pa)Ductwork operates at low/neutral pressure
Maintenance scopeFilter replacement & terminal housing wipe-downFan motor, speed control & filter servicing
Best first use caseDucted cleanrooms with central plant air handlersLarge modular ceiling grids & flexible cleanrooms
Key sizing inputAirflow (m³/h) + available central static pressureAirflow (m³/h) + ceiling coverage % + power
04 / Procurement Protocol

Information Required for Cleanroom System Sizing

Provide room cleanliness classification, room dimensions, ceiling void depth, airflow pattern, and terminal preferences.
STEP 01

Cleanliness & ACH

Define ISO 14644 target class, room dimensions (L×W×H), and calculated air changes per hour (ACH).

STEP 02

Terminal Architecture

Select Passive GFK/GCFK (central AHU static pressure) or Distributed FFU (fan-powered ceiling).

STEP 03

Staged Filtration Train

Choose G4 pre-filter, F7/F8 medium bags/V-banks, and H14/U15 terminal HEPA filter elements.

STEP 04

Pressure Cascades

Define positive/negative room pressure differentials and size residual-pressure relief dampers.

Engineering Handoff

Submit Cleanroom Parameters for Engineering Sizing

YONGFAN cleanroom engineers will verify filter face velocities, calculate loaded-system pressure drops, model ceiling grid coverage, and supply scan-test certificates.

Required Cleanliness: ISO Class 1–8 / GMP A–D
Room Dimensions & Ceiling Void Depth (mm)
Terminal Preference: GFK, GCFK (150mm), or FFU
Total Clean Airflow Rate (m³/h) & ACH Target
Room Pressure Differential (ΔP in Pa vs adjacent)
Molecular Gas Risk: AMC Gas Analysis if present
05 / Manufacturing QA

EN 1822 Scan Testing & Cleanroom Quality Standards

Every HEPA/ULPA filter is scan-tested for pinholes; FFU modules undergo sound and vibration factory testing.
HEPA Scan QA

100% Pinhole Scan Testing

Every H13–U16 filter is individual scan-tested with automated probe arrays to verify zero media or frame leaks per EN 1822.

Casing QA

Terminal Housing Integrity

GFK and GCFK diffuser housings are leakage-tested to ensure zero bypass between duct connection and ceiling grid.

FFU Run QA

FFU Acoustic & Flow Verification

FFU fan assemblies are bench-tested for 900 m³/h airflow, ≤54 dB(A) noise level, and dynamic impeller balance.

Clean Packaging

Cleanroom Class 100 Packaging

Filters and cleanroom terminals are double-polyethylene sealed in a Class 100 environment before crating.

Standard HEPA & GFK: Standard sizes (610×610, 1220×610) dispatched in 10–15 working days. FFU & Custom GCFK: FFU modules and custom depth diffusers dispatched with scan-test reports.
06 / Engineering Knowledge

Cleanroom Air Filtration FAQ

Direct engineering answers regarding HEPA capabilities, GFK vs FFU, shallow ceiling options, and room pressure.

Does a HEPA filter create a cleanroom by itself?

No. The filter removes particles from the air passing through it. Final room performance also depends on airflow volume, ACH, terminal sealing, room leakage, airflow pattern, and commissioning.

Why use primary and medium filters before HEPA?

They capture coarse dust and sub-micron particles before they reach the high-efficiency terminal filter, extending expensive HEPA life and saving fan static pressure.

What is the difference between GFK and FFU?

GFK is a passive HEPA diffuser box that relies on upstream AHU fan pressure. FFU integrates its own fan and HEPA filter into the ceiling module.

When should I use GCFK?

Use GCFK when ceiling void clearance is very tight. It has an ultra-thin 150 mm depth and delivers 600 to 1,200 m³/h at ≤120 Pa initial resistance.

What airflow does the YONGFAN FFU provide?

The standard FFU module delivers 900 m³/h airflow with noise ≤54 dB(A) and ≥99.99% efficiency at 0.3 µm on AC 220 V 50 Hz.

Can VAV be used in a cleanroom?

Yes, where variable zone airflow is needed and the room pressure control sequence is specifically engineered to maintain positive pressure under all part-load conditions.

How is positive room pressure maintained?

By supplying more treated air than is exhausted/returned plus room leakage. A counterweighted residual-pressure relief damper relieves excess air to maintain the set ΔP.

Do I need chemical filtration in a cleanroom?

Only if your process has Airborne Molecular Contamination (AMC) risks from corrosive gases or VOCs. Particulate HEPA filters do not remove molecular gases.

Should HEPA filters be selected by efficiency alone?

No. Rated airflow, initial DP, dirty DP budget, face velocity, dimensions, sealing method (gel vs gasket), and AHU fan pressure all matter.

How should I plan filter replacement?

Monitor differential pressure across each filter stage. Replace pre-filters at 2× initial DP, medium filters per schedule, and HEPA filters before fan static limits are reached.

07 / Application Boundaries

Cleanroom Air Filtration Engineering Boundaries

Key operational boundaries to respect when designing cleanroom air filtration systems.
Boundary 01 / ISO Class

Not Standalone ISO Class

A YONGFAN HEPA filter, GFK, GCFK, or FFU does not independently guarantee an ISO 14644 cleanroom class without full room qualification.

Boundary 02 / Passive vs FFU

GFK Is Not an FFU

GFK is a passive diffuser requiring external AHU pressure; do not specify GFK where localized ceiling fan power is required.

Boundary 03 / AMC Gases

HEPA Particle Limit

HEPA and ULPA filters capture suspended particles only; specify gas-phase chemical filtration where molecular gases must be removed.

Boundary 04 / Room Sealing

Installed Integrity Test

Factory scan testing certifies the filter; on-site aerosol challenge testing (DOP/PAO) is required after installation to verify ceiling grid integrity.

08 / Engineering Handoff

Plan Your Cleanroom Air Filtration System

Send your cleanroom dimensions, target cleanliness class, available ceiling void height, and AHU static pressure. YONGFAN application engineers will verify filter stages, size GFK/FFU ceiling grids, and supply certified submittals.

Primary Pre-Filters (CG, CCB, CY, G3/G4)Medium Bag & V-Bank Filters (ZF, ZZH, F7/F8)HEPA / ULPA Filters (H13–U16, Scan Tested)GFK HEPA Diffusers (500–3,000 m³/h, 69–220mm)GCFK Ultra-Thin Diffusers (150 mm Depth)FFU Fan Filter Units (900 m³/h, ≤54 dB(A))Residual-Pressure Relief DampersYFVAV-S-T100 Cleanroom VAV & Plenums
YONGFAN cleanroom engineers reviewing ceiling grid layouts and HEPA filter scan test reports
Direct Cleanroom Engineering Handoff
Staged filter train calculations, ceiling grid modeling & EN 1822 scan test certificates.